TY - JOUR
AU - Calvert, Clara
AU - Carruthers, Jade
AU - Denny, Cheryl
AU - Donaghy, Jack
AU - Hopcroft, Lisa E.M.
AU - Hopkins, Leanne
AU - Goulding, Anna
AU - Lindsay, Laura
AU - McLaughlin, Terry
AU - Moore, Emily
AU - Taylor, Bob
AU - Loane, Maria
AU - Dolk, Helen
AU - Morris, Joan
AU - Auyeung, Bonnie
AU - Bhaskaran, Krishnan
AU - Gibbons, Cheryl L.
AU - Katikireddi, Srinivasa Vittal
AU - O'Leary, Maureen
AU - Mcallister, David
AU - Shi, Ting
AU - Simpson, Colin R
AU - Robertson, Chris
AU - Sheikh, Aziz
AU - Stock, Sarah J E
AU - Wood, Rachael
PY - 2023
DA - January
TI - A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection
JO - Nature Communications
VL - 14
DO - https://doi.org/10.1038/s41467-022-35771-8
AB - Evidence on associations between COVID-19 vaccination or SARS-CoV-2 infection and the risk of congenital anomalies is limited. Here we report a national, population-based, matched cohort study using linked electronic health records from Scotland (May 2020-April 2022) to estimate the association between COVID-19 vaccination and, separately, SARS-CoV-2 infection between six weeks pre-conception and 19 weeks and six days gestation and the risk of [1] any major congenital anomaly and [2] any non-genetic major congenital anomaly. Mothers vaccinated in this pregnancy exposure period mostly received an mRNA vaccine (73.7% Pfizer-BioNTech BNT162b2 and 7.9% Moderna mRNA-1273). Of the 6,731 babies whose mothers were vaccinated in the pregnancy exposure period, 153 had any anomaly and 120 had a non-genetic anomaly. Primary analyses find no association between any vaccination and any anomaly (adjusted Odds Ratio [aOR]=1.01, 95% Confidence Interval [CI]=0.83-1.24) or non-genetic anomalies (aOR=1.00, 95% CI=0.81-1.22). Primary analyses also find no association between SARS-CoV-2 infection and any anomaly (aOR=1.02, 95% CI=0.66-1.60) or non-genetic anomalies (aOR=0.94, 95% CI=0.57-1.54). Findings are robust to sensitivity analyses. These data provide reassurance on the safety of vaccination, in particular mRNA vaccines, just before or in early pregnancy.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/9b881dcf-75b5-4070-bf59-ba071357683b
KW - Coronavirus (COVID-19)
ER