TY - JOUR
AU - Cantoni, Diego
AU - Grove, Joe
PY - 2023
DA - March
TI - Low hanging fruit for combatting SARS‐CoV‐2?
JO - EMBO Reports
DO - https://doi.org/10.15252/embr.202356979
AB - Entry of SARS-CoV-2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin-converting enzyme-2). This makes ACE2 an attractive target for therapeutic intervention in COVID-19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin-dependent degradation, resulting in the inhibition of SARS-CoV-2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS-2 and related coronaviruses.
PB - Embopress
UR - https://eprints.gla.ac.uk/294336/
KW - Coronavirus (COVID-19)
ER