TY - JOUR
AU - Kotagiri, Prasanti
AU - Mescia, Federica
AU - Hanson, Aimee L.
AU - Turner, Lorinda
AU - Bergamaschi, Laura
AU - Peñalver, Ana
AU - Richoz, Nathan
AU - Moore, Stephen D
AU - Ortmann, Brian M
AU - Dunmore, Benjamin J.
AU - Morgan, Michael D.
AU - Tuong, Zewen Kelvin
AU - Göttgens, Berthold
AU - Toshner, Mark
AU - Hess, Christoph
AU - Maxwell, Patrick H.
AU - Clatworthy, Menna R.
AU - Nathan, James A.
AU - Bradley, John R.
AU - Lyons, Paul A.
AU - Burrows, Natalie
AU - Smith, Kenneth G.C.
AU - Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration
PY - 2022
DA - February
TI - The impact of hypoxia on B cells in COVID-19
JO - eBioMedicine
VL - 77
DO - https://doi.org/10.1016/j.ebiom.2022.103878
AB - Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This presentation resembles the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19.
PB - Elsevier
UR - https://hdl.handle.net/2164/20597
KW - Coronavirus (COVID-19)
ER