TY - JOUR
AU - Dowell, Alexander C.
AU - Lancaster, Tara
AU - Bruton, Rachel
AU - Ireland, Georgina
AU - Bentley, Christopher
AU - Sylla, Panagiota
AU - Zuo, Jianmin
AU - Scott, Sam
AU - Jadir, Azar
AU - Begum, Jusnara
AU - Roberts, Thomas
AU - Stephens, Christine
AU - Ditta, Shabana
AU - Shepherdson, Rebecca
AU - Powell, Annabel A.
AU - Brent, Andrew J.
AU - Brent, Bernadette
AU - Baawuah, Frances
AU - Okike, Ifeanyichukwu O.
AU - Beckmann, Joanne
AU - Ahmad, Shazaad
AU - Aiano, Felicity
AU - Garstang, Joanna
AU - Ramsay, Mary E.
AU - Azad, Rafaq
AU - Waiblinger, Dagmar
AU - Willett, Brian
AU - Wright, John
AU - Ladhani, Shamez N.
AU - Moss, Paul
PY - 2023
DA - June
TI - Immunological imprinting of humoral immunity to SARS-CoV-2 in children
JO - Nature Communications
VL - 14
DO - https://doi.org/10.1038/s41467-023-39575-2
AB - Omicron variants of SARS-CoV-2 are globally dominant and infection rates are very high in children. We measure immune responses following Omicron BA.1/2 infection in children aged 6-14 years and relate this to prior and subsequent SARS-CoV-2 infection or vaccination. Primary Omicron infection elicits a weak antibody response with poor functional neutralizing antibodies. Subsequent Omicron reinfection or COVID-19 vaccination elicits increased antibody titres with broad neutralisation of Omicron subvariants. Prior pre-Omicron SARS-CoV-2 virus infection or vaccination primes for robust antibody responses following Omicron infection but these remain primarily focussed against ancestral variants. Primary Omicron infection thus elicits a weak antibody response in children which is boosted after reinfection or vaccination. Cellular responses are robust and broadly equivalent in all groups, providing protection against severe disease irrespective of SARS-CoV-2 variant. Immunological imprinting is likely to act as an important determinant of long-term humoral immunity, the future clinical importance of which is unknown.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/302090/
KW - Coronavirus (COVID-19)
KW - Children, young people and families
ER