TY - JOUR
AU - Lindsay, Laura
AU - Calvert, Clara
AU - Shi, Ting
AU - Carruthers, Jade
AU - Denny, Cheryl
AU - Donaghy, Jack
AU - Hopcroft, Lisa E.M.
AU - Hopkins, Leanne
AU - Goulding, Anna
AU - McLaughlin, Terry
AU - Moore, Emily
AU - Taylor, Bob
AU - Bhaskaran, Krishnan
AU - Katikireddi, Srinivasa Vittal
AU - McCabe, Ronan
AU - McCowan, Colin
AU - Simpson, Colin R.
AU - Robertson, Chris
AU - Sheikh, Aziz
AU - Wood, Rachael
AU - Stock, Sarah J.
PY - 2023
DA - August
TI - Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study
JO - Nature Communications
VL - 14
DO - https://doi.org/10.1038/s41467-023-40965-9
AB - Understanding the impact of SARS-CoV-2 infection and COVID-19 vaccination in pregnancy on neonatal and maternal outcomes informs clinical decision-making. Here we report a national, population-based, matched cohort study to investigate associations between SARS-CoV-2 infection and, separately, COVID-19 vaccination just before or during pregnancy and the risk of adverse neonatal and maternal outcomes among women in Scotland with a singleton pregnancy ending at ≥20 weeks gestation. Neonatal outcomes are stillbirth, neonatal death, extended perinatal mortality, preterm birth (overall, spontaneous, and provider-initiated), small-for-gestational age, and low Apgar score. Maternal outcomes are admission to critical care or death, venous thromboembolism, hypertensive disorders of pregnancy, and pregnancy-related bleeding. We use conditional logistic regression to derive odds ratios adjusted for socio-demographic and clinical characteristics (aORs). We find that infection is associated with an increased risk of preterm (aOR=1.36, 95% Confidence Interval [CI] = 1.16–1.59) and very preterm birth (aOR = 1.90, 95% CI 1.20–3.02), maternal admission to critical care or death (aOR=1.72, 95% CI = 1.39–2.12), and venous thromboembolism (aOR = 2.53, 95% CI = 1.47–4.35). We find no evidence of increased risk for any of our outcomes following vaccination. These data suggest SARS-CoV-2 infection during pregnancy is associated with adverse neonatal and maternal outcomes, and COVID-19 vaccination remains a safe way for pregnant women to protect themselves and their babies against infection.
PB - Springer Nature
UR - https://strathprints.strath.ac.uk/86614/
KW - Coronavirus (COVID-19)
KW - Maternity and early years
ER