TY - JOUR
AU - Sosenko, Filip
AU - Mackay, Daniel F.
AU - Pell, Jill P.
AU - Hatton, Chris
AU - Jani, Bhautesh D.
AU - Cairns, Deborah
AU - Ward, Laura
AU - Henderson, Angela
AU - Fleming, Michael
AU - Nijhof, Dewy
AU - Melville, Craig
AU - CVD-COVID-UK/COVID-IMPACT Consortium
PY - 2023
DA - October
TI - Understanding covid-19 outcomes among people with intellectual disabilities in England
JO - BMC Public Health
VL - 23
DO - https://doi.org/10.1186/s12889-023-16993-x
AB - Background: Evidence from the UK from the early stages of the covid-19 pandemic showed that people with Intellectual Disabilities (ID) had higher rates of covid-19 mortality than people without ID. However, estimates of the magnitude of risk vary widely; different studies used different time periods; and only early stages of the pandemic have been analysed. Existing analyses of risk factors have also been limited. The objective of this study was to investigate covid-19 mortality rates, hospitalisation rates, and risk factors in people with ID in England up to the end of 2021. Methods: Retrospective cohort study of all people with a laboratory-confirmed SARS-CoV-2 infection or death involving covid-19. Datasets covering primary care, secondary care, covid-19 tests and vaccinations, prescriptions, and deaths were linked at individual level. Results: Covid-19 carries a disproportionately higher risk of death for people with ID, above their already higher risk of dying from other causes, in comparison to those without ID. Around 2,000 people with ID had a death involving covid-19 in England up to the end of 2021; approximately 1 in 180. The covid-19 standardized mortality ratio was 5.6 [95% CI 5.4, 5.9]. People with ID were also more likely to be hospitalised for covid-19 than people without ID. The main determinants of severe covid-19 outcomes (deaths and/or hospitalisations) in both populations were age, multimorbidity and vaccination status. The key factor responsible for the higher risk of severe covid-19 in the ID population was a much higher prevalence of multimorbidity in this population. AstraZeneca vaccine was slightly less effective in preventing severe covid-19 outcomes among people with ID than among people without ID. Conclusions: People with ID should be considered a priority group in future pandemics, such as shielding and vaccinations.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/308745/
KW - Coronavirus (COVID-19)
KW - Minority groups
ER