TY - JOUR
AU - Sidhu, Jasmin K.
AU - Siggins, Matthew K.
AU - Liew, Felicity
AU - Russell, Clark D.
AU - Uruchurtu, Ashley S S
AU - Davis, Christopher
AU - Turtle, Lance C.W.
AU - Moore, Shona C
AU - Hardwick, Hayley E.
AU - Oosthuyzen, Wilna
AU - Thomson, Emma C
AU - Semple, Malcolm G.
AU - Baillie, J. Kenneth
AU - Openshaw, Peter J.M.
AU - ISARIC4C Investigators
AU - Thwaites, Ryan S.
PY - 2023
DA - December
TI - Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19
JO - Journal of Infectious Diseases
DO - https://doi.org/10.1093/infdis/jiad590
AB - BACKGROUND: While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and relate these to disease progression and peripheral inflammation.
PB - Oxford University Press
UR - https://www.research.ed.ac.uk/en/publications/bed8141e-e4f2-482e-beae-1d084fe9ae37
KW - Coronavirus (COVID-19)
ER