TY - JOUR
AU - Wei, Jia
AU - Stoesser, Nicole
AU - Matthews, Philippa C.
AU - Khera, Tarnjit
AU - Gethings, Owen
AU - Diamond, Ian
AU - Studley, Ruth
AU - Taylor, Nick
AU - Peto, Timothy E.A.
AU - Walker, A. Sarah
AU - Pouwels, Koen B.
AU - Eyre, David W.
AU - Rourke, Emma
AU - Thomas, Tina
AU - Pienaar, Dawid
AU - Preece, Joy
AU - Crofts, Sarah
AU - Lloyd, Lina
AU - Bowen, Michelle
AU - Ayoubkhani, Daniel
AU - Black, Russell
AU - Felton, Antonio
AU - Crees, Megan
AU - Jones, Joel
AU - Sutherland, Esther
AU - Crook, Derrick W.
AU - Pritchard, Emma
AU - Vihta, Karina-Doris
AU - Howarth, Alison
AU - Marsden, Brian D.
AU - Chau, Kevin K.
AU - Ferreira, Lucas Martins
AU - Dejnirattisai, Wanwisa
AU - Mongkolsapaya, Juthathip
AU - Hoosdally, Sarah
AU - Cornall, Richard
AU - Stuart, David I.
AU - Screaton, Gavin
AU - Lythgoe, Katrina A.
AU - Bonsall, David
AU - Golubchik, Tanya
AU - Fryer, Helen
AU - Newton, John N.
AU - Bell, John I.
AU - Cox, Stuart
AU - Paddon, Kevin
AU - James, Tim
AU - House, Thomas
AU - Robotham, Julie
AU - Birrell, Paul J.
AU - Jordan, Helena
AU - Sheppard, Tim
AU - Athey, Graham
AU - Moody, Dan
AU - Curry, Leigh
AU - Brereton, Pamela
AU - Jarvis, Ian
AU - Godsmark, Anna
AU - Morris, George
AU - Mallick, Bobby
AU - Eeles, Phil
AU - Hay, Jodie
AU - VanSteenhouse, Harper
AU - Lee, Jessica
AU - White, Sean
AU - Evans, Tim
AU - Bloemberg, Lisa
AU - Allison, Katie
AU - Pandya, Anouska
AU - Davis, Sophie
AU - Conway, David I.
AU - MacLeod, Margaret
AU - Cunningham, Chris
PY - 2024
DA - February
TI - Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population
JO - Nature Communications
VL - 15
DO - https://doi.org/10.1038/s41467-024-44973-1
AB - SARS-CoV-2 reinfections increased substantially after Omicron variants emerged. Large-scale community-based comparisons across multiple Omicron waves of reinfection characteristics, risk factors, and protection afforded by previous infection and vaccination, are limited. Here we studied ~45,000 reinfections from the UK’s national COVID-19 Infection Survey and quantified the risk of reinfection in multiple waves, including those driven by BA.1, BA.2, BA.4/5, and BQ.1/CH.1.1/XBB.1.5 variants. Reinfections were associated with lower viral load and lower percentages of self-reporting symptoms compared with first infections. Across multiple Omicron waves, estimated protection against reinfection was significantly higher in those previously infected with more recent than earlier variants, even at the same time from previous infection. Estimated protection against Omicron reinfections decreased over time from the most recent infection if this was the previous or penultimate variant (generally within the preceding year). Those 14–180 days after receiving their most recent vaccination had a lower risk of reinfection than those &gt;180 days from their most recent vaccination. Reinfection risk was independently higher in those aged 30–45 years, and with either low or high viral load in their most recent previous infection. Overall, the risk of Omicron reinfection is high, but with lower severity than first infections; both viral evolution and waning immunity are independently associated with reinfection.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/324872/
KW - Coronavirus (COVID-19)
ER