TY - JOUR
AU - Siddiqui, Ruqaiyyah
AU - Mungroo, Mohammad Ridwane
AU - Khan, Naveed Ahmed
PY - 2021
DA - March
TI - SARS-CoV-2 invasion of the central nervous: a brief review
JO - Hospital Practice
EP - 163
VL - 49
IS - 3
DO - https://doi.org/10.1080/21548331.2021.1887677
AB - There is increasing evidence of the ability of the novel coronavirus to invade the central nervous system (CNS). But how does a respiratory virus invade the highly protected CNS? Here, we reviewed available literature and case reports to determine CNS involvement in COVID-19, and to identify potential regions of the brain that may be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible route of entry into the brain to identify its pathogenicity. Based on the symptoms, the parietal lobe and the cerebellum are the likely targets of SARS-CoV-2; however, further work is needed to elucidate this. The presence of ACE2, used by SARS-CoV-2 for cell entry, in the brain as well as detection of the virus in the cerebrospinal fluid, further assert that SARS-COV-2 targets the brain, and therefore, medical practitioners should take that into account when dealing with patients suffering from COVID-19.
PB - Taylor and Francis
UR - https://researchportal.hw.ac.uk/en/publications/0e8e01a3-371e-4cbf-80c2-c47816704fc7
KW - Coronavirus (COVID-19)
KW - Hospital care
ER