TY - JOUR
AU - Lucinde, Ruth K.
AU - Mugo, Daisy
AU - Bottomley, Christian
AU - Karani, Angela
AU - Gardiner, Elizabeth
AU - Aziza, Rabia
AU - Gitonga, John N.
AU - Nyagwange, James
AU - Karanja, Henry
AU - Nyagwange, James
AU - Tuju, James
AU - Wanjiku, Perpetual
AU - Nzomo, Edward
AU - Kamuri, Evans
AU - Thuranira, Kaugiria
AU - Agunda, Sarah
AU - Nyutu, Gideon
AU - Etyang, Anthony O.
AU - Adetifa, I.M.O.
AU - Kagucia, Eunice
AU - Uyoga, Sophie
AU - Otiende, Mark
AU - Otieno, Edward
AU - Ndwiga, Leonard
AU - Agoti, Charles N.
AU - Aman, Rashid
AU - Mwangangi, Mercy
AU - Amoth, Patrick
AU - Kasera, Kadondi
AU - Nyaguara, Amek
AU - Ng’ang’a, Wangari
AU - Ochola, Lucy B.
AU - Namdala, Emukule
AU - Gaunya, Oscar
AU - Okuku, Rosemary
AU - Barasa, Edwine
AU - Bejon, Philip
AU - Tsofa, Benjamin
AU - Ochola-Oyier, Lynette Isabella
AU - Warimwe, George M.
AU - Agweyu, Ambrose
AU - Scott, J. Anthony G.
AU - Gallagher, Katherine E.
PY - 2022
DA - October
TI - Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21
JO - PLoS ONE
VL - 17
IS - 10
DO - https://doi.org/10.1371/journal.pone.0265478
AB - The high proportion of SARS-CoV-2 infections that have remained undetected presents a challenge to tracking the progress of the pandemic and estimating the extent of population immunity.&lt;h4&gt;Methods&lt;/h4&gt;We used residual blood samples from women attending antenatal care services at three hospitals in Kenya between August 2020 and October 2021and a validated IgG ELISA for SARS-Cov-2 spike protein and adjusted the results for assay sensitivity and specificity. We fitted a two-component mixture model as an alternative to the threshold analysis to estimate of the proportion of individuals with past SARS-CoV-2 infection.&lt;h4&gt;Results&lt;/h4&gt;We estimated seroprevalence in 2,981 women; 706 in Nairobi, 567 in Busia and 1,708 in Kilifi. By October 2021, 13% of participants were vaccinated (at least one dose) in Nairobi, 2% in Busia. Adjusted seroprevalence rose in all sites; from 50% (95%CI 42-58) in August 2020, to 85% (95%CI 78-92) in October 2021 in Nairobi; from 31% (95%CI 25-37) in May 2021 to 71% (95%CI 64-77) in October 2021 in Busia; and from 1% (95% CI 0-3) in September 2020 to 63% (95% CI 56-69) in October 2021 in Kilifi. Mixture modelling, suggests adjusted cross-sectional prevalence estimates are underestimates; seroprevalence in October 2021 could be 74% in Busia and 72% in Kilifi.&lt;h4&gt;Conclusions&lt;/h4&gt;There has been substantial, unobserved transmission of SARS-CoV-2 in Nairobi, Busia and Kilifi Counties. Due to the length of time since the beginning of the pandemic, repeated cross-sectional surveys are now difficult to interpret without the use of models to account for antibody waning.
PB - Public Library of Science
UR - https://eprints.gla.ac.uk/325328/
KW - Coronavirus (COVID-19)
KW - Maternity and early years
KW - Hospital care
ER