@article{Etyang_A-2021_176554,
title = {Seroprevalence of antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 among healthcare workers in Kenya},
author = {Etyang, A. and Lucinde, R. and Karanja, H. and Kalu, C. and Mugo, D. and Nyagwange, J. and Gitonga, J. and Tuju, J. and Wanjiku, P. and Karani, A. and Mutua, S. and Maroko, H. and Nzomo, E. and Maitha, E. and Kamuri, E. and Kaugiria, T. and Weru, J. and Ochola, L. and Kilimo, N. and Charo, S. and Emukule, N. and Moracha, W. and Mukabi, D. and Okuku, R. and Ogutu, M. and Angujo, B. and Otiende, M. and Bottomley, C. and Otieno, E. and Ndwiga, L. and Nyaguara, A. and Voller, S. and Agoti, C. and Nokes, D. and Ochola-Oyier, L. and Aman, R. and Amoth, P. and Mwangangi, M. and Kasera, K. and Ng’ang’a, W. and Adetifa, I. and Kagucia, E. and Gallagher, K. and Uyoga, S. and Tsofa, B. and Barasa, E. and Bejon, P. and Scott, J. and Agweyu, A. and Warimwe, G.},
month = {apr},
year = {2021},
abstract = {Background: Few studies have assessed the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Africa. We report findings from a survey among HCWs in 3 counties in Kenya. Methods: We recruited 684 HCWs from Kilifi (rural), Busia (rural), and Nairobi (urban) counties. The serosurvey was conducted between 30 July and 4 December 2020. We tested for immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay. Assay sensitivity and specificity were 92.7 (95% CI, 87.9-96.1) and 99.0% (95% CI, 98.1-99.5), respectively. We adjusted prevalence estimates, using bayesian modeling to account for assay performance. Results: The crude overall seroprevalence was 19.7% (135 of 684). After adjustment for assay performance, seroprevalence was 20.8% (95% credible interval, 17.5%–24.4%). Seroprevalence varied significantly (P &lt; .001) by site: 43.8% (95% credible interval, 35.8%–52.2%) in Nairobi, 12.6% (8.8%–17.1%) in Busia and 11.5% (7.2%–17.6%) in Kilifi. In a multivariable model controlling for age, sex, and site, professional cadre was not associated with differences in seroprevalence. Conclusion: These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.},
pages = {288-293},
volume = {74},
issue = {2},
journal = {Clinical Infectious Diseases},
publisher = {Oxford University Press},
url = {https://doi.org/10.1093/cid/ciab346},
}
