TY - JOUR
AU - Copland, Emma
AU - Patone, Martina
AU - Saatci, Defne
AU - Handunnetthi, Lahiru
AU - Hirst, Jennifer
AU - Hunt, David P.J. 
AU - Mills, Nicholas L.
AU - Moss, Paul
AU - Sheikh, Aziz
AU - Coupland, Carol A.C.
AU - Harnden, Anthony
AU - Robertson, Chris
AU - Hippisley-Cox, Julia
PY - 2024
DA - May
TI - Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England
JO - Nature Communications
VL - 15
DO - https://doi.org/10.1038/s41467-024-47745-z
AB - The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes after COVID-19 vaccination and infection. In 5-11-year-olds, we found no increased risks of adverse events 1–42 days following vaccination with BNT162b2, mRNA-1273 or ChAdOX1. In 12-17-year-olds, we estimated 3 (95%CI 0–5) and 5 (95%CI 3–6) additional cases of myocarditis per million following a first and second dose with BNT162b2, respectively. An additional 12 (95%CI 0–23) hospitalisations with epilepsy and 4 (95%CI 0–6) with demyelinating disease (in females only, mainly optic neuritis) were estimated per million following a second dose with BNT162b2. SARS-CoV-2 infection was associated with increased risks of hospitalisation from seven outcomes including multisystem inflammatory syndrome and myocarditis, but these risks were largely absent in those vaccinated prior to infection. We report a favourable safety profile of COVID-19 vaccination in under-18s.
PB - Springer Nature
UR - https://strathprints.strath.ac.uk/89377/
KW - Coronavirus (COVID-19)
KW - Children, young people and families
ER