TY - JOUR
AU - Roberts, Thomas
AU - Uwenedi, Grace
AU - Bruton, Rachel
AU - McIlroy, Graham
AU - Damery, Sarah
AU - Sylla, Panagiota
AU - Logan, Nicola
AU - Scott, Sam
AU - Lau, May
AU - Elzaidi, Ahmed
AU - Plass, Siobhan
AU - Mallick, Soumyajit
AU - Spencer, Katie
AU - Stephens, Christine
AU - Bentley, Christopher
AU - Pratt, Guy
AU - Zuo, Jianmin
AU - Paneesha, Shankara
AU - Willett, Brian
AU - Moss, Paul
AU - Parry, Helen
PY - 2024
DA - January
TI - Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia
JO - Blood Cancer Journal
VL - 14
DO - https://doi.org/10.1038/s41408-023-00940-5
AB - Cancer patients who are immune suppressed remain at increased risk from COVID-19 and have recently been prioritised for additional booster bivalent vaccines. Despite this, previous studies have shown that humoral and cellular immune responses often fail to reach levels comparable to the general population following booster doses. The emergence of the omicron variant of SARS-CoV-2 has necessitated the deployment of modified bivalent mRNA vaccines that direct the synthesis of spike protein from Omicron in combination with ancestral spike. Bivalent booster vaccines have shown utility in general population studiesbut there is little understanding of their relative immunogenicity in patients with immune suppression.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/322265/
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
ER