TY - JOUR
AU - Macdonald, Calum
AU - Palmateer, Norah E.
AU - McAuley, Andrew
AU - Lindsay, Laura
AU - Hasan, Taimoor
AU - Hameed, Safraj Shahul
AU - Hall, Elliot
AU - Jeffrey, Karen
AU - Grange, Zoë
AU - Gousias, Petros
AU - Mavin, Sally
AU - Jarvis, Lisa
AU - Cameron, Claire
AU - Daines, Luke
AU - Tibble, Holly
AU - Simpson, Colin R.
AU - McCowan, Colin
AU - Katikireddi, Srinivasa Vittal
AU - Rudan, Igor
AU - Fagbamigbe, Adeniyi Francis
AU - Ritchie, Lewis
AU - Swallow, Ben
AU - Moss, Paul
AU - Robertson, Chris
AU - Sheikh, Aziz
AU - Murray, Josie
PY - 2024
DA - June
TI - Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland
JO - Npj Vaccines
VL - 9
DO - https://doi.org/10.1038/s41541-024-00898-w
AB - Several population-level studies have described individual clinical risk factors associated with suboptimal antibody responses following COVID-19 vaccination, but none have examined multimorbidity. Others have shown that suboptimal post-vaccination responses offer reduced protection to subsequent SARS-CoV-2 infection; however, the level of protection from COVID-19 hospitalisation/death remains unconfirmed. We use national Scottish datasets to investigate the association between multimorbidity and testing antibody-negative, examining the correlation between antibody levels and subsequent COVID-19 hospitalisation/death among double-vaccinated individuals. We found that individuals with multimorbidity ( ≥ five conditions) were more likely to test antibody-negative post-vaccination and 13.37 [6.05–29.53] times more likely to be hospitalised/die from COVID-19 than individuals without conditions. We also show a dose-dependent association between post-vaccination antibody levels and COVID-19 hospitalisation or death, with those with undetectable antibody levels at a significantly higher risk (HR 9.21 [95% CI 4.63–18.29]) of these serious outcomes compared to those with high antibody levels
PB - Springer Nature
UR - https://strathprints.strath.ac.uk/89659/
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
ER