TY - JOUR
AU - Mousavi, Seyedeh Zahra
AU - Rahmanian, Mojdeh
AU - Sami, Ashkan
PY - 2022
DA - March
TI - Organ-specific or personalized treatment for COVID-19: rationale, evidence, and potential candidates
JO - Functional & Integrative Genomics 
EP - 433
VL - 22
DO - https://doi.org/10.1007/s10142-022-00841-z
AB - Although extrapulmonary manifestations of coronavirus disease 2019 (COVID-19) are increasingly reported, no effective therapeutic strategy for these multisystemic complications is available due to a poor understanding of the pathophysiology of COVID-19 multiorgan involvement. In this study, differentially expressed genes (DEGs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected extrapulmonary organs including human pluripotent stem cells (hPSCs)-derived liver organoids and choroid plexus organoids besides transformed lung alveolar (A549) cells were analyzed. First, pathway enrichment analysis was done to compare the underlying biological pathways enriched upon SARS-CoV-2 infection in different organs. Then, these lists of DEGs were used in a connectivity map (CMap)-based drug repurposing experiment. Also, protein–protein interaction (PPI) network analysis was done to compare the associated hub genes. The results revealed different biological pathways and genes responsible for SARS-CoV-2 multisystemic pathogenesis based on the organ involved that highlighted the need for considering organ-specific treatments or even personalized therapy. Besides, some FDA-approved drugs were proposed as the potential therapeutic candidates for each infected cell line.
PB - Springer Nature
UR - https://napier-repository.worktribe.com/output/3735026/organ-specific-or-personalized-treatment-for-covid-19-rationale-evidence-and-potential-candidates
KW - Coronavirus (COVID-19)
ER