@article{Berry_C-2023_180056,
title = {Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study},
author = {Berry, C. and Lomholt-Welch, H. and Morrow, A. and Sykes, R. and Saleh, M. and Zahra, B. and MacIntosh, A. and Kamdar, A. and Bagot, C. and Bayes, H. and Blyth, K. and Bulluck, H. and Carrick, D. and Church, C. and Corcoran, D. and Findlay, I. and Gibson, V. and Gillespie, L. and Grieve, D. and Barrientos, P. and Ho, A. and Lang, N. and Lowe, D. and Lennie, V. and Macfarlane, P. and Mayne, K. and Mark, P. and McConnachie, A. and McGeoch, R. and Nordin, S. and Payne, A. and Rankin, A. and Robertson, K. and Ryan, N. and Roditi, G. and Sattar, N. and Stobo, D. and Touyz, R. and Veldtman, G. and Weeden, S. and Weir, R. and Watkins, S. and Welsh, P. and Mangion, K. and Allwood-Spiers, S.},
month = {nov},
year = {2023},
abstract = {Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function.},
pages = {235-245},
volume = {7},
issue = {4},
journal = {Heart and Mind},
publisher = {Wolters Kluwer},
url = {https://doi.org/10.4103/hm.HM-D-23-00037},
}
