TY - JOUR
AU - Lawson, Claire Alexandra
AU - Moss, Alastair James
AU - Arnold, Jayanth Ranjit
AU - Bagot, Catherine
AU - Banerjee, Amitava
AU - Berry, Colin
AU - Greenwood, John P.
AU - Hughes, Alun D.
AU - Khunti, Kamlesh
AU - Mills, Nicholas L.
AU - Neubauer, Stefan
AU - Raman, Betty
AU - Sattar, Naveed
AU - Leavy, Olivia C.
AU - Richardson, Matthew
AU - Elneima, Omer
AU - McAuley, Hamish Jc
AU - Shikotra, Aarti
AU - Singapuri, Amisha
AU - Sereno, Marco
AU - Saunders, Ruth
AU - Harris, Victoria C.
AU - Houchen-Wolloff, Linzy
AU - Greening, Neil J.
AU - Harrison, Ewen M.
AU - Docherty, Annemarie B.
AU - Lone, Nazir I.
AU - Quint, Jennifer K.
AU - Chalmers, James D.
AU - Ho, Ling-Pei
AU - Horsley, Alex
AU - Marks, Michael
AU - Poinasamy, Krisnah
AU - Evans, Rachael A.
AU - Wain, Louise V.
AU - Brightling, Chris E
AU - McCann, Gerry P.
PY - 2024
DA - May
TI - Long COVID and cardiovascular disease: a prospective cohort study
JO - Openheart
VL - 11
IS - 1
DO - https://doi.org/10.1136/openhrt-2024-002662
AB - Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.
PB - BMJ Publishing Group
UR - https://eprints.gla.ac.uk/327599/
KW - Coronavirus (COVID-19)
ER