TY - JOUR
AU - Al Saihati, Hajer A.
AU - Dessouky, Arigue A.
AU - Salim, Rabab F.
AU - Elgohary, Islam
AU - El-Sherbiny, Mohamed
AU - Ali, Fares E.M.
AU - Moustafa, Mahmoud M.A.
AU - Shaheen, Dalia
AU - Forsyth, Nicholas Robert
AU - Badr, Omnia A.
AU - Ebrahim, Nesrine
PY - 2024
DA - September
TI - MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation
JO - Stem Cell Research & Therapy
VL - 15
DO - https://doi.org/10.1186/s13287-024-03889-9
AB - Background Coronavirus disease 2019 (COVID-19) has created a global pandemic with significant morbidity and mortality. SARS-CoV-2 primarily infects the lungs and is associated with various organ complications. Therapeutic approaches to combat COVID-19, including convalescent plasma and vaccination, have been developed. However, the high mutation rate of SARS-CoV-2 and its ability to inhibit host T-cell activity pose challenges for effective treatment. Mesenchymal stem cells (MSCs) and their extracellular vesicles (MSCs–EVs) have shown promise in COVID-19 therapy because of their immunomodulatory and regenerative properties. MicroRNAs (miRNAs) play crucial regulatory roles in various biological processes and can be manipulated for therapeutic purposes.
PB - Springer Nature
UR - https://hdl.handle.net/2164/24476
KW - Coronavirus (COVID-19)
ER