TY - JOUR
AU - Nyirenda, James
AU - Hardy, Olympia M.
AU - Da Silva Filho, Joao
AU - Herder, Vanessa
AU - Attipa, Charalampos
AU - Ndovi, Charles
AU - Siwombo, Memory
AU - Namalima, Takondwa Rex
AU - Suwedi, Leticia
AU - Ilia, George
AU - Nyasulu, Watipenge
AU - Ngulube, Thokozile
AU - Nyirenda, Deborah
AU - Mvaya, Leonard
AU - Phiri, Joseph
AU - Chasweka, Dennis
AU - Eneya, Chisomo
AU - Makwinja, Chikondi
AU - Phiri, Chisomo
AU - Ziwoya, Frank
AU - Tembo, Abel
AU - Makwangwala, Kingsley
AU - Khoswe, Stanley
AU - Banda, Peter
AU - Morton, Ben
AU - Hilton, Orla
AU - Lawrence, Sarah
AU - Freire dos Reis, Monique
AU - Cardoso Melo, Gisely
AU - Guimaraes de Lacerda, Marcus Vinicius
AU - Maranhão Costa, Fabio Trindade
AU - Monteiro, Wuelton Marcelo
AU - Carlos de Lima Ferreira, Luiz
AU - Johnson, Carla
AU - McGuinness, Dagmara
AU - Jambo, Kondwani C.
AU - Haley, Michael
AU - Kumwenda, Benjamin
AU - Palmarini, Massimo
AU - Denno, Donna M.
AU - Voskuijl, Wieger
AU - Kamiza, Steve Bvuobvuo
AU - Barnes, Kayla G.
AU - Couper, Kevin
AU - Marti, Matthias
AU - Otto, Thomas D.
AU - Moxon, Christopher
PY - 2024
DA - November
TI - Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
JO - Nature Medicine
DO - https://doi.org/10.1038/s41591-024-03354-3
AB - Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTDs), including coronavirus disease 2019 (COVID-19), but there are minimal data from African settings where HIV, malaria and other environmental exposures may affect disease pathobiology and treatment targets. In this study, we used histology and high-dimensional imaging to characterize fatal lung disease in Malawian adults with (n = 9) and without (n = 7) COVID-19, and we generated single-cell transcriptomics data from lung, blood and nasal cells. Data integration with other cohorts showed a conserved COVID-19 histopathological signature, driven by contrasting immune and inflammatory mechanisms: in US, European and Asian cohorts, by type I/III interferon (IFN) responses, particularly in blood-derived monocytes, and in the Malawian cohort, by response to IFN-γ in lung-resident macrophages. HIV status had minimal impact on histology or immunopathology. Our study provides a data resource and highlights the importance of studying the cellular mechanisms of disease in underrepresented populations, indicating shared and distinct targets for treatment.
PB - Springer Nature
UR - https://eprints.gla.ac.uk/340663/
KW - Coronavirus (COVID-19)
ER