TY - JOUR
AU - Daynes, Enya
AU - Evans, Rachael A.
AU - Greening, Neil J.
AU - Bishop, Nicolette C.
AU - Yates, Thomas
AU - Lozano-Rojas, Daniel
AU - Ntotsis, Kimon
AU - Richardson, Matthew
AU - Baldwin, Molly
AU - Hamrouni, Malik
AU - Hume, Emily
AU - McAuley, Hamish J. C.
AU - Mills, George E.
AU - Megaritis, Dimitrios
AU - Roberts, Matthew D
AU - Bolton, Charlotte E.
AU - Chalmers, James D.
AU - Chalder, Trudie
AU - Docherty, Annemarie B.
AU - Elneima, Omer
AU - Harrison, Ewen M
AU - Harris, Victoria C.
AU - Ho, Ling-Pei
AU - Horsley, Alexander
AU - Houchen-Wolloff, Linzy
AU - Leavy, Olivia C.
AU - Marks, Michael
AU - Poinasamy, Krishna
AU - Quint, Jennifer K.
AU - Raman, Betty
AU - Saunders, Ruth M.
AU - Shikotra, Aarti
AU - Singapuri, Amisha
AU - Sereno, Marco
AU - Terry, Sarah
AU - Wain, Louise V.
AU - Man, William D-C
AU - Echevarria, Carlos
AU - Vogiatzis, Ioannis
AU - Brightling, Christopher E.
AU - Singh, Sally J.
PY - 2025
DA - February
TI - Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): A randomised controlled trial of exercise-based rehabilitation
JO - European Respiratory Journal
DO - https://doi.org/10.1183/13993003.02152-2024
AB - Objective Post-COVID syndrome involves prolonged symptoms with multi-system and functional impairment lasting at least 12 weeks after acute COVID-19. We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing Post-COVID syndrome following a hospitalisation of acute COVID-19. Design This single-blind randomised controlled trial compared two COVID exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with Post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote eight-week program of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following eight weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping. Results 181 participants (55% male, mean [sd] age 59 [12] years, length of hospital stay 12 [19] days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 [95% CI 19 to 85]m, p=0·002) and remote rehabilitation (mean 34 [95% CI 1 to 66]m, p=0·047) compared to usual care alone. There were no differences between groups for HRQoL of self-reported symptoms. Analysis of immune markers revealed significant increases in naïve and memory CD8+ T cells following face-to-face rehabilitation versus usual care alone (p&lt;0·001, n=31). Conclusion Exercise-based rehabilitation improved short-term exercise capacity in Post-COVID syndrome following an acute hospitalisation and showed potential for beneficial immunomodulatory effects.
PB - ERS Publications
UR - https://discovery.dundee.ac.uk/en/publications/a9ca5160-9c01-4c25-8e48-d52e398677f6
KW - Coronavirus (COVID-19)
KW - Hospital care
KW - Diet, healthy weight and physical activity
ER