@article{RECOVERY_Collaborative_Group-2025_200288,
title = {Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial},
author = {RECOVERY Collaborative Group},
month = {feb},
year = {2025},
abstract = {Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive mechanical ventilation, including high-flow nasal oxygen, continuous positive airway pressure and bilevel positive airway pressure ventilation, and invasive mechanical ventilation or extra-corporeal membrane oxygenation), but the balance of efficacy and safety in patients receiving ventilatory support is uncertain.},
volume = {81},
journal = {eClinicalMedicine},
publisher = {Elsevier},
url = {https://doi.org/10.1016/j.eclinm.2025.103080},
}
