TY - JOUR
AU - RECOVERY Collaborative Group
PY - 2025
DA - February
TI - Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
JO - eClinicalMedicine
VL - 81
DO - https://doi.org/10.1016/j.eclinm.2025.103080
AB - Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive mechanical ventilation, including high-flow nasal oxygen, continuous positive airway pressure and bilevel positive airway pressure ventilation, and invasive mechanical ventilation or extra-corporeal membrane oxygenation), but the balance of efficacy and safety in patients receiving ventilatory support is uncertain.
PB - Elsevier
UR - https://hdl.handle.net/10023/31861
KW - Coronavirus (COVID-19)
KW - Hospital care
ER