TY - JOUR
AU - Mahalingasivam, Viyaasan
AU - Zheng, Bang
AU - Wing, Kevin
AU - Parker, Edward P.K.
AU - Bhaskaran, Krishnan
AU - Jesus Carrero, Juan
AU - Jayacodi, Sandra
AU - Jumbo, Edith
AU - Miah, Tamanna
AU - Gracey, Brian
AU - Tazare, John
AU - Santhakumaran, Shalini
AU - Mathur, Rohini
AU - Costello, Ruth E.
AU - Herrett, Emily
AU - Wen, Qing
AU - Hartney, Thomas
AU - Douglas, Ian J.
AU - Green, Amelia C.A.
AU - Fisher, Louis
AU - Curtis, Helen J.
AU - Walker, Alex J.
AU - Mackenna, Brian
AU - Hulme, William J.
AU - Mehrkar, Amir
AU - Bacon, Sebastian C.J.
AU - Goldacre, Ben
AU - Williamson, Elizabeth J.
AU - Nitsch, Dorothea
AU - Mansfield, Kathryn E.
AU - Tomlinson, Laurie
PY - 2025
DA - June
TI - Long-term kidney outcomes after COVID-19: a matched cohort study using the OpenSAFELY platform
JO - The Lancet Regional Health Europe
DO - http://dx.doi.org/10.1016/j.lanepe.2025.101338
AB - Background: COVID-19 severe enough to require hospitalisation is commonly associated with acute kidney injury. However, it remains unclear whether COVID-19 leads to long-term kidney outcomes in the broader population. Methods: We undertook a population-based, matched cohort study. With the approval of NHS England, we used primary and secondary care electronic health records from England using the OpenSAFELY-TPP platform. We compared people with and without COVID-19 using fully-adjusted, stratified, cause-specific Cox models for kidney failure, 50% reduction in kidney function, and death. Findings: Overall, all outcomes were increased after COVID-19 over the course of follow-up (HR for kidney failure 1.93 [95% CI 1.84–2.03]). Hazards of kidney failure were greatest after hospitalisation (HR 7.74 [95% CI 7.00–8.56]) and remained increased beyond 180 days of follow-up. There was no evidence of increased risk in those not hospitalised (HR 0.85 [95% CI 0.79–0.90]). Increased kidney failure was more pronounced in black ethnicity (HR 4.50 [95% CI 2.92–6.92]) compared to white ethnicity (HR 1.82 [95% CI 1.71–1.94]). Amongst those hospitalised with COVID-19, there was no attenuation of kidney failure between the first wave (HR 8.74 [95% CI 6.88–11.08]) and the Omicron wave (HR 8.36 [95% CI 6.81–10.27]). Interpretation: We observed increased long-term kidney outcomes in people hospitalised with COVID-19, as well as notable ethnic differences. Our results suggest strategies to minimise severe COVID-19 should continue to be optimised among vulnerable groups, and that kidney function should be proactively monitored after hospital discharge. Funding: National Institute for Health and Care Research.
PB - Elsevier
UR - https://eprints.gla.ac.uk/358987/
KW - Coronavirus (COVID-19)
KW - Hospital care
ER