@article{Lee_D-2022_214182,
title = {Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children},
author = {Lee, D. and Le Pen, J. and Yatim, A. and Dong, B. and Aquino, Y. and Ogishi, M. and Pescarmona, R. and Talouarn, E. and Rinchai, D. and Zhang, P. and Perret, M. and Liu, Z. and Jordan, I. and Elmas Bozdemir, S. and Bayhan, G. and Beaufils, C. and Bizien, L. and Bisiaux, A. and Lei, W. and Hasan, M. and Chen, J. and Gaughan, C. and Asthana, A. and Libri, V. and Luna, J. and Jaffré, F. and Hoffmann, H. and Michailidis, E. and Moreews, M. and Seeleuthner, Y. and Bilguvar, K. and Mane, S. and Flores, C. and Zhang, Y. and Arias, A. and Bailey, R. and Schlüter, A. and Milisavljevic, B. and Bigio, B. and Le Voyer, T. and Materna, M. and Gervais, A. and Moncada-Velez, M. and Pala, F. and Lazarov, T. and Levy, R. and Neehus, A. and Rosain, J. and Peel, J. and Chan, Y. and Morin, M. and Pino-Ramirez, R. and Belkaya, S. and Lorenzo, L. and Anton, J. and Delafontaine, S. and Toubiana, J. and Bajolle, F. and Fumadó, V. and DeDiego, M. and Fidouh, N. and Rozenberg, F. and Pérez-Tur, J. and Chen, S. and Evans, T. and Geissmann, F. and Lebon, P. and Weiss, S. and Bonnet, D. and Duval, X. and Pan-Hammarström, Q. and Planas, A. and Meyts, I. and Haerynck, F. and Pujol, A. and Sancho-Shimizu, V. and Dalgard, C. and Bustamante, J. and Puel, A. and Boisson-Dupuis, S. and Boisson, B. and Maniatis, T. and Zhang, Q. and Bastard, P. and Notarangelo, L. and Béziat, V. and Perez de Diego, R. and Rodriguez-Gallego, C. and Su, H. and Lifton, R. and Jouanguy, E. and Cobat, A. and Alsina, L. and Keles, S. and Haddad, E. and Abel, L. and Belot, A. and Quintana-Murci, L. and Rice, C. and Silverman, R. and Zhang, S. and Casanova, J. and COV-Contact-Cohort and Covid Human Genetic Effort},
month = {dec},
year = {2022},
abstract = {Multisystem inflammatory syndrome in children (MIS-C) is a severe, unexplained complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with an estimated prevalence of ~1 per 10,000 infected children. It typically occurs 4 weeks after infection, without hypoxemic pneumonia. Affected children present with fever, rash, abdominal pain, myocarditis, and other clinical features reminiscent of Kawasaki disease, including lymphadenopathy, coronary aneurysm, and high levels of biological markers of acute inflammation. Sustained monocyte activation is consistently reported as a key immunological feature of MIS-C. A more specific immunological abnormality is the polyclonal expansion of CD4+and CD8+T cells bearing the T cell receptor Vβ21.3. The root cause of MIS-C and its immunological and clinical features remains unknown.},
volume = {379},
issue = {6632},
journal = {Science},
publisher = {American Association for the Advancement of Science},
url = {https://doi.org/10.1126/science.abo3627},
}
