@article{Marchal_A-2024_214942,
title = {Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection},
author = {Marchal, A. and Cirulli, E. and Neveux, I. and Bellos, E. and Thwaites, R. and Schiabor Barrett, K. and Zhang, Y. and Nemes-Bokun, I. and Kalinova, M. and Catchpole, A. and Tangye, S. and Spaan, A. and Lack, J. and Ghosn, J. and Burdet, C. and Gorochov, G. and Tubach, F. and Hausfater, P. and Abel, L. and Aiuti, A. and Covid Human Genetic Effort},
month = {apr},
year = {2024},
abstract = {Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between theHLA-B∗15:01allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, includingHLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the threeHLA-B∗15:01individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.},
volume = {5},
issue = {3},
journal = {Human Genetics and Genomics Advances},
publisher = {Elsevier},
url = {https://doi.org/10.1016/j.xhgg.2024.100300},
}
