TY - JOUR
AU - Marchal, Astrid
AU - Cirulli, Elizabeth T.
AU - Neveux, Iva
AU - Bellos, Evangelos
AU - Thwaites, Ryan S.
AU - Schiabor Barrett, Kelly M.
AU - Zhang, Yu
AU - Nemes-Bokun, Ivana
AU - Kalinova, Mariya
AU - Catchpole, Andrew
AU - Tangye, Stuart G.
AU - Spaan, András N.
AU - Lack, Justin B.
AU - Ghosn, Jade
AU - Burdet, Charles
AU - Gorochov, Guy
AU - Tubach, Florence
AU - Hausfater, Pierre
AU - Abel, Laurent
AU - Aiuti, Alessandro
AU - Covid Human Genetic Effort
PY - 2024
DA - April
TI - Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
JO - Human Genetics and Genomics Advances
VL - 5
IS - 3
DO - https://doi.org/10.1016/j.xhgg.2024.100300
AB - Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between theHLA-B∗15:01allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, includingHLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the threeHLA-B∗15:01individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/b214ab2c-c5ce-46b8-93ba-85d91ce6165a
KW - Coronavirus (COVID-19)
ER