@article{Stewart_I-2023_220006,
title = {Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study},
author = {Stewart, I. and Jacob, J. and George, P. and Molyneaux, P. and Porter, J. and Allen, R. and Aslani, S. and Baillie, J. and Barratt, S. and Beirne, P. and Bianchi, S. and Blaikley, J. and Chalmers, J. and Chambers, R. and Chadhuri, N. and Coleman, C. and Collier, G. and Denneny, E. and Elneima, O. and Evans, R. and Fabbri, L. and Gibbons, M. and Gleeson, F. and Gooptu, B. and Greening, N. and Guio, B. and Hall, I. and Hanley, N. and Harrison, E. and Heightman, M. and Hillman, T. and Horsley, A. and Houchen-Wolloff, L. and Jarrold, I. and Johnson, S. and Jones, M. and Khan, F. and Lawson, R. and Marks, M. and McAuley, H. and Mehta, P. and Parekh, D. and Hanley, K. and Platé, M. and Pearl, J. and Poinasamy, K. and Quint, J. and Raman, B. and Richardson, M. and Rivera-Ortega, P. and Saunders, L. and Semple, M. and Sereno, M. and Shikotra, A. and Simpson, A. and Singapuri, A. and Spears, M. and Spencer, L. and Stanel, S. and Thickett, D. and Thorpe, M. and Walker, S. and Weatherley, N. and Weeks, M. and Wild, J. and Wootton, D. and Brightling, C. and Ho, L. and Wain, L. and Jenkins, G. and Docherty, A. and Harris, V. and Leavy, O. and Lone, N. and Saunders, R. and Smith, D. and Thompson, A. and Walsh, S.},
month = {mar},
year = {2023},
abstract = {Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19) and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to progressive lung damage. Objectives: The UK Interstitial Lung Disease Consortium (UKILD) post–COVID-19 study interim analysis was planned to estimate the prevalence of residual lung abnormalities in people hospitalized with COVID-19 on the basis of risk strata. Methods: The PHOSP–COVID-19 (Post-Hospitalization COVID-19) study was used to capture routine and research follow-up within 240 days from discharge. Thoracic computed tomography linked by PHOSP–COVID-19 identifiers was scored for the percentage of residual lung abnormalities (ground-glass opacities and reticulations). Risk factors in linked computed tomography were estimated with Bayesian binomial regression, and risk strata were generated. Numbers within strata were used to estimate posthospitalization prevalence using Bayesian binomial distributions. Sensitivity analysis was restricted to participants with protocol-driven research follow-up. Measurements and Main Results: The interim cohort comprised 3,700 people. Of 209 subjects with linked computed tomography (median, 119 d; interquartile range, 83–155), 166 people (79.4%) had more than 10% involvement of residual lung abnormalities. Risk factors included abnormal chest X-ray (risk ratio [RR], 1.21; 95% credible interval [CrI], 1.05–1.40), percent predicted DLCO less than 80% (RR, 1.25; 95% CrI, 1.00–1.56), and severe admission requiring ventilation support (RR, 1.27; 95% CrI, 1.07–1.55). In the remaining 3,491 people, moderate to very high risk of residual lung abnormalities was classified at 7.8%, and posthospitalization prevalence was estimated at 8.5% (95% CrI, 7.6–9.5), rising to 11.7% (95% CrI, 10.3–13.1) in the sensitivity analysis. Conclusions: Residual lung abnormalities were estimated in up to 11% of people discharged after COVID-19–related hospitalization. Health services should monitor at-risk individuals to elucidate long-term functional implications.},
volume = {207},
issue = {6},
journal = {American Journal of Respiratory and Critical Care Medicine},
publisher = {American Thoracic Society},
url = {https://doi.org/10.1164/rccm.202203-0564OC},
}
