TY - JOUR
AU - Schuermans, Art
AU - Verstraete, Andreas
AU - Lammi, Vilma
AU - Nakanishi, Tomoko
AU - Ardissino, Maddalena
AU - Van den Eynde, Jef
AU - Sun, Benjamin B.
AU - Georgakis, Marios K.
AU - Guillen-Guio, Beatriz
AU - Wain, Louise V.
AU - Brightling, Christopher E.
AU - van Weyenbergh, Johan
AU - Lewandowski, Adam J.
AU - Raman, Betty
AU - Zeberg, Hugo
AU - Ollila, Hanna M.
AU - Burgess, Stephen
AU - Natarajan, Pradeep
AU - Honigberg, Michael C.
AU - Freson, Kathleen
AU - Vanassche, Thomas
AU - Verhamme, Peter
AU - The PHOSP-COVID Collaborative Group
PY - 2024
DA - December
TI - Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry
JO - MedRXiv
DO - https://doi.org/10.1101/2024.05.17.24307553
AB - SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from multiple organs. Current hypotheses on mechanisms underlying long COVID include persistent inflammation and thromboembolism; however, compelling evidence from humans is limited and causal associations remain unclear. Here, we tested the association of thromboembolism-related genetic variants with long COVID in the Long COVID Host Genetics Initiative ( n cases =3,018; n controls =994,582). Primary analyses revealed that each unit increase in the log-odds of genetically predicted venous thromboembolism risk was associated with 1.21-fold odds of long COVID (95%CI: 1.08-1.35; P =1.2×10 -3 ). This association was independent of acute COVID-19 severity, robust across genetic instruments and methods, and replicated in external datasets for both venous thromboembolism and long COVID. Downstream analyses using gene-specific instruments, along with protein and gene expression data, suggested the protease-activated receptor 1 (PAR-1) as a potential molecular contributor to long COVID. These findings provide human genetic evidence implicating thromboembolism in long COVID pathogenesis.
PB - MedRxiv
UR - https://eprints.gla.ac.uk/374287/
KW - Coronavirus (COVID-19)
ER