@article{Townsend_A-2021_26889,
title = {A haemagglutination test for rapid detection of antibodies to SARS-CoV-2},
author = {Townsend, A. and Rijal, P. and Xiao, J. and Tan, T. and Huang, K. and Schimanski, L. and Huo, J. and Gupta, N. and Rahikainen, R. and Matthews, P. and Crook, D. and Hoosdally, S. and Dunachie, S. and Barnes, E. and Street, T. and Conlon, C. and Frater, J. and Arancibia-Cárcamo, C. and Rudkin, J. and Stoesser, N. and Karpe, F. and Neville, M. and Ploeg, R. and Oliveira, M. and Roberts, D. and Lamikanra, A. and Tsang, H. and Bown, A. and Vipond, R. and Mentzer, A. and Knight, J. and Kwok, A. and Screaton, G. and Mongkolsapaya, J. and Dejnirattisai, W. and Supasa, P. and Klenerman, P. and Dold, C. and Baillie, J. and Moore, S. and Openshaw, P. and Semple, M. and Turtle, L. and Ainsworth, M. and Allcock, A. and Beer, S. and Bibi, S. and Skelly, D. and Stafford, L. and Jeffery, K. and O'Donnell, D. and Clutterbuck, E. and Espinosa, A. and Mendoza, M. and Georgiou, D. and Lockett, T. and Martinez, J. and Perez, E. and Gallardo Sanchez, V. and Scozzafava, G. and Sobrinodiaz, A. and Thraves, H. and Joly, E.},
month = {mar},
year = {2021},
abstract = {Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, and for seeking evidence for a level of antibody that may be protective against COVID-19 disease. Several high-performance commercial tests have been described, but these require centralised laboratory facilities that are comparatively expensive, and therefore not available universally. Red cell agglutination tests do not require special equipment, are read by eye, have short development times, low cost and can be applied at the Point of Care. Here we describe a quantitative Haemagglutination test (HAT) for the detection of antibodies to the receptor binding domain of the SARS-CoV-2 spike protein. The HAT has a sensitivity of 90% and specificity of 99% for detection of antibodies after a PCR diagnosed infection. We will supply aliquots of the test reagent sufficient for ten thousand test wells free of charge to qualified research groups anywhere in the world.},
volume = {12},
journal = {Nature Communications},
publisher = {Springer Nature},
url = {https://doi.org/10.1038/s41467-021-22045-y},
}
