TY - JOUR
AU - Townsend, Alain
AU - Rijal, Pramila
AU - Xiao, Julie
AU - Tan, Tiong Kit
AU - Huang, Kuan-Ying A.
AU - Schimanski, Lisa
AU - Huo, Jiandong
AU - Gupta, Nimesh
AU - Rahikainen, Rolle
AU - Matthews, Philippa C.
AU - Crook, Derrick W.
AU - Hoosdally, Sarah
AU - Dunachie, Susanna
AU - Barnes, Eleanor
AU - Street, Teresa
AU - Conlon, Chris
AU - Frater, John
AU - Arancibia-Cárcamo, Carolina V.
AU - Rudkin, Justine
AU - Stoesser, Nicole
AU - Karpe, Fredrik
AU - Neville, Matthew
AU - Ploeg, Rutger J.
AU - Oliveira, Marta S.
AU - Roberts, David J.
AU - Lamikanra, Abigail A.
AU - Tsang, Hoi Pat
AU - Bown, Abbie
AU - Vipond, Richard
AU - Mentzer, Alexander J.
AU - Knight, Julian C.
AU - Kwok, Andrew J
AU - Screaton, Gavin R
AU - Mongkolsapaya, Juthathip
AU - Dejnirattisai, Wanwisa
AU - Supasa, Piyada
AU - Klenerman, Paul
AU - Dold, Christina
AU - Baillie, J. Kenneth
AU - Moore, Shona C.
AU - Openshaw, Peter J.M.
AU - Semple, Malcolm G.
AU - Turtle, Lance C.W.
AU - Ainsworth, Mark
AU - Allcock, Alice
AU - Beer, Sally
AU - Bibi, Sagida
AU - Skelly, Donal
AU - Stafford, Lizzy
AU - Jeffery, Katie
AU - O'Donnell, Denise
AU - Clutterbuck, Elizabeth A.
AU - Espinosa, Alexis
AU - Mendoza, Maria
AU - Georgiou, Dominique
AU - Lockett, Teresa
AU - Martinez, Jose
AU - Perez, Elena
AU - Gallardo Sanchez, Veronica
AU - Scozzafava, Giuseppe
AU - Sobrinodiaz, Alberto
AU - Thraves, Hannah
AU - Joly, Etienne
PY - 2021
DA - March
TI - A haemagglutination test for rapid detection of antibodies to SARS-CoV-2
JO - Nature Communications
VL - 12
DO - https://doi.org/10.1038/s41467-021-22045-y
AB - Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, and for seeking evidence for a level of antibody that may be protective against COVID-19 disease. Several high-performance commercial tests have been described, but these require centralised laboratory facilities that are comparatively expensive, and therefore not available universally. Red cell agglutination tests do not require special equipment, are read by eye, have short development times, low cost and can be applied at the Point of Care. Here we describe a quantitative Haemagglutination test (HAT) for the detection of antibodies to the receptor binding domain of the SARS-CoV-2 spike protein. The HAT has a sensitivity of 90% and specificity of 99% for detection of antibodies after a PCR diagnosed infection. We will supply aliquots of the test reagent sufficient for ten thousand test wells free of charge to qualified research groups anywhere in the world.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/portal/en/publications/a-haemagglutination-test-for-rapid-detection-of-antibodies-to-sarscov2(cefbac80-ecc7-4a56-8fa8-70ce4c00791d).html
KW - Coronavirus (COVID-19)
ER