TY - JOUR
AU - Hughes, Ellen C.
AU - Amat, Julien A.R.
AU - Haney, Joanne
AU - Parr, Yasmin A.
AU - Logan, Nicola
AU - Palmateer, Norah E.
AU - Nickbakhsh, Sema
AU - Ho, Antonia
AU - Cherepanov, Peter
AU - Rosa, Annachiara
AU - McAuley, Andrew
AU - Broos, Alice
AU - Herbert, Imogen
AU - Arthur, Ursula
AU - Szemiel, Agnieszka
AU - Roustan, Chloe
AU - Dickson, Elizabeth M.
AU - Gunson, Rory N.
AU - Viana, Mafalda
AU - Willett, Brian J.
AU - Murcia, Pablo R.
PY - 2020
DA - December
TI - SARS-CoV-2 serosurveillance in a patient population reveals differences in virus exposure and antibody-mediated immunity according to host demography and healthcare setting
JO - Journal of Infectious Diseases
EP - 980
VL - 223
IS - 6
DO - https://doi.org/10.1093/infdis/jiaa788
AB - Identifying drivers of SARS-CoV-2 exposure and quantifying population immunity is crucial to prepare for future epidemics. We performed a serial cross-sectional serosurvey throughout the first pandemic wave among patients from the largest health board in Scotland. Screening of 7480 patient sera showed a weekly seroprevalence ranging from 0.10% to 8.23% in primary and 0.21% to 17.44% in secondary care, respectively. Neutralisation assays showed that around half of individuals who tested positive by ELISA assay, developed highly neutralising antibodies, mainly among secondary care patients. We estimated the individual probability of SARS-CoV-2 exposure and quantified associated risk factors. We show that secondary care patients, males and 45-64-year-olds exhibit a higher probability of being seropositive. The identification of risk factors and the differences in virus neutralisation activity between patient populations provided insights into the patterns of virus exposure during the first pandemic wave and shed light on what to expect in future waves.
PB - Oxford University Press
UR - http://eprints.gla.ac.uk/227349/
KW - Coronavirus (COVID-19)
ER