@article{Niemi_M-2021_60409,
title = {Mapping the human genetic architecture of COVID-19},
author = {Niemi, M. and Karjalainen, J. and Liao, R. and Neale, B. and Daly, M. and Ganna, A. and Pathak, G. and Andrews, S. and Kanai, M. and Veerapen, K. and Fernandez-Cadenas, I. and Schulte, E. and Striano, P. and Marttila, M. and Minica, C. and Marouli, E. and Karim, M. and Wendt, F. and Savage, J. and Sloofman, L. and Butler-Laporte, G. and Kim, H. and Kanoni, S. and Okada, Y. and Byun, J. and Han, Y. and Uddin, M. and Smith, G. and Willer, C. and Buxbaum, J. and Mehtonen, J. and Finucane, H. and Cordioli, M. and Martin, A. and Zhou, W. and Pasaniuc, B. and Julienne, H. and Aschard, H. and Shi, H. and Yengo, L. and Polimanti, R. and Ghoussaini, M. and Schwartzentruber, J. and Dunham, I. and Chwialkowska, K. and Francescatto, M. and Trankiem, A. and Balaconis, M. and Davis, L. and Lee, S. and Priest, J. and Renieri, A. and Sankaran, V. and van Heel, D. and Deelen, P. and Richards, J. and Nakanishi, T. and Biesecker, L. and Kerchberger, V. and Baillie, J. and Mari, F. and Bernasconi, A. and Baillie, S. and Canakoglu, A. and Wolford, B. and Faucon, A. and Dutta, A. and Schurmann, C. and Harry, E. and Birney, E. and Nguyen, H. and Nasir, J. and Kaunisto, M. and Solomonson, M. and Dueker, N. and Vadgama, N. and Limou, S. and Rahmouni, S. and Mbarek, H. and Darwish, D. and Uddin, M. and Albertos, R. and Pérez-Tur, J. and Li, R. and Folkersen, L. and Moltke, I. and Koelling, N. and Teumer, A. and Kousathanas, A. and Utrilla, A. and Verdugo, R. and Zárate, R. and Medina-Gómez, C. and Gómez-Cabrero, D. and Carnero-Montoro, E. and Cadilla, C. and Moreno-Estrada, A. and Garmendia, A. and Moya, L. and Sedaghati-Khayat, B. and Boua, P. and Favé, M. and Francioli, L. and Lemaçon, A. and Migeotte, I. and Patel, S. and Varnai, R. and Szentpeteri, J. and Sipeky, C. and Colombo, F. and von Hohenstaufen, K. and Lio, P. and Vallerga, C. and Wang, Q. and Tanigawa, Y. and Im, H. and Han, C. and Song, H. and Lim, J. and Lee, Y. and Kim, S. and Im, S. and Atanasovska, B. and Ahmad, H. and Boer, C. and Jansen, P. and Franke, L. and Kaja, E. and Pasko, D. and Kennis-Szilagyi, I. and Kornilov, S. and Prijatelj, V. and Prokić, I. and Sivanadhan, I. and Perumal, S. and Esmaeeli, S. and Pearson, N. and Auton, A. and Shelton, J. and Shastri, A. and Filshtein-Sonmez, T. and Coker, D. and Symons, A. and Esparza-Gordillo, J. and Aslibekyan, S. and O’Connell, J. and Ye, C. and Weldon, C. and Perera, M. and O’Leary, K. and Tuck, M. and O’Brien, T. and Meltzer, D. and O’Donnell, P. and Nutescu, E. and Yang, G. and Alarcon, C. and Herrmann, S. and Mazurek, S. and Banagan, J. and Hamidi, Z. and Barbour, A. and Raffat, N. and Moreno, D. and Friedman, P. and Ferwerda, B. and van de Beek, D. and Brouwer, M. and Vlaar, A. and Wiersinga, W. and Posthuma, D. and Tissink, E. and Koos Zwinderman, A. and Uffelmann, E. and van Agtmael, M. and Algera, A. and van Baarle, F. and Bax, D. and Beudel, M. and Jan Bogaard, H. and Bomers, M. and Bonta, P. and Bos, L. and Botta, M. and de 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month = {dec},
year = {2021},
abstract = {The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191, 2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.},
pages = {472-477},
volume = {600},
issue = {7889},
journal = {Nature},
publisher = {Springer Nature},
url = {http://dx.doi.org/10.1038/s41586-021-03767-x},
}
