TY - JOUR
AU - Peckham, Daniel
AU - McDermott, Michael F.
AU - Savic, Sinisa
AU - Mehta, Anil
PY - 2020
DA - July
TI - COVID-19 meets cystic fibrosis: for better or worse?
JO - Genes and Immunity
EP - 262
VL - 21
IS - 4
DO - https://doi.org/10.1038/s41435-020-0103-y
AB - Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.
PB - Springer Nature
UR - https://discovery.dundee.ac.uk/en/publications/21f1a768-006f-4b92-8b02-41d3a42f5f80
KW - Coronavirus (COVID-19)
ER