@article{Hufsky_F-2020_100983,
title = {Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research},
author = {Hufsky, F. and Lamkiewicz, K. and Almeida, A. and Aouacheria, A. and Arighi, C. and Bateman, A. and Baumbach, J. and Beerenwinkel, N. and Brandt, C. and Cacciabue, M. and Chuguransky, S. and Drechsel, O. and Finn, R. and Fritz, A. and Fuchs, S. and Hattab, G. and Hauschild, A. and Heider, D. and Hoffmann, M. and Hölzer, M. and Hoops, S. and Kaderali, L. and Kalvari, I. and von Kleist, M. and Kmiecinski, R. and Kühnert, D. and Lasso, G. and Libin, P. and List, M. and Löchel, H. and Martin, M. and Martin, R. and Matschinske, J. and McHardy, A. and Mendes, P. and Mistry, J. and Navratil, V. and Nawrocki, E. and O'Toole, Á. and Ontiveros-Palacios, N. and Petrov, A. and Rangel-Pineros, G. and Redaschi, N. and Reimering, S. and Reinert, K. and Reyes, A. and Richardson, L. and Robertson, D. and Sadegh, S. and Singer, J. and Theys, K. and Upton, C. and Welzel, M. and Williams, L. and Marz, M.},
month = {nov},
year = {2020},
abstract = {SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of the virus. In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies. For each tool, we briefly describe its use case and how it advances research specifically for SARS-CoV-2. All tools are free to use and available online, either through web applications or public code repositories.},
pages = {642-663},
volume = {22},
issue = {2},
journal = {Briefings in Bioinformatics},
publisher = {Oxford University Press},
url = {https://doi.org/10.1093/bib/bbaa232},
}
