@article{Curtis_H-2021_103417,
title = {Trends and clinical characteristics of COVID-19 vaccine recipients: A federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY},
author = {Curtis, H. and Inglesby, P. and Morton, C. and Mackenna, B. and Green, A. and Hulme, W. and Walker, A. and Morley, J. and Mehrkar, A. and Bacon, S. and Hickman, G. and Bates, C. and Croker, R. and Evans, D. and Ward, T. and Cockburn, J. and Davy, S. and Bhaskaran, K. and Schultze, A. and Rentsch, C. and Williamson, E. and Rowan, A. and Fisher, L. and McDonald, H. and Tomlinson, L. and Mathur, R. and Drysdale, H. and Eggo, R. and Wing, K. and Wong, A. and Forbes, H. and Parry, J. and Hester, F. and Harper, S. and O'Hanlon, S. and Eavis, A. and Jarvis, R. and Avramov, D. and Griffiths, P. and Fowles, A. and Parkes, N. and Douglas, I. and Evans, S. and Smeeth, L. and Goldacre, B. and The OpenSAFELY Collaborative},
month = {dec},
year = {2021},
abstract = {Background On 8 December 2020 NHS England administered the first COVID-19 vaccination. Aim To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout. Design and setting With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY. Method Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described. Results A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose. Conclusion The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.},
pages = {e51-e62},
volume = {72},
issue = {714},
journal = {British Journal of General Practice},
publisher = {Royal College of General Practitioners},
url = {https://doi.org/10.3399/BJGP.2021.0376},
}
