@article{Kurdi_A-2023_111587,
title = {Evaluation of duration of antibiotic therapy across hospitals in Scotland including the impact of COVID-19 pandemic: a segmented interrupted time series analysis},
author = {Kurdi, A. and Platt, N. and Morrison, A. and Proud, E. and Gronkowski, K. and Mueller, T. and Seaton, R. and Malcolm, W. and Bennie, M.},
month = {feb},
year = {2023},
abstract = {Background: Little is known about the duration of antibiotic use in hospital settings. We evaluated the duration of hospital antibiotic therapy (as a quality indicator proxy) for four commonly prescribed antibiotics (amoxicillin, co-amoxiclav, doxycycline and flucloxacillin) including the assessment of COVID-19 impact. Research design/methods: A repeated, cross-sectional study using the Hospital Electronic Prescribing and Medicines Administration system (January/2019-March/2022). Monthly median duration of therapy/duration categories were calculated, stratified by routes of administration, age and sex. Impact of COVID-19 was assessed using segmented time-series analysis. Results: There were significant variations in the median duration of therapy across routes of administration (P 7 days compared to oral or IV. Duration of therapy overall differed significantly by age. Some small statistically significant changes in the level/trends of duration of therapy were observed in the post- COVID-19 period. Conclusions: No evidence for prolonged duration of therapy were observed, even during COVID-19 pandemic. Duration of IV therapy was relatively short suggesting timely clinical review and consideration of IV to oral switch. Longer duration of therapy was observed among older patients.},
journal = {Expert Review of Anti-infective Therapy},
publisher = {Taylor and Francis},
url = {https://publichealthscotland.scot/id/111587},
}
