@article{Hamilton_F-2023_112220,
title = {Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A mendelian randomisation study},
author = {Hamilton, F. and Thomas, M. and Arnold, D. and Palmer, T. and Moran, E. and Mentzer, A. and Maskell, N. and Baillie, J. and Summers, C. and Hingorani, A. and MacGowan, A. and Khandaker, G. and Mitchell, R. and Smith, G. and Ghazal, P. and Timpson, N.},
month = {jan},
year = {2023},
abstract = {BACKGROUND: Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in IL6R known to down-regulate IL-6 signalling are associated with improved Coronavirus Disease 2019 (COVID-19) outcomes, a finding later confirmed in randomised trials of IL-6 receptor antagonists (IL6RAs). We hypothesised that blockade of IL6R could also improve outcomes in sepsis.},
volume = {20},
issue = {1},
journal = {PLoS Medicine},
publisher = {Public Library of Science},
url = {https://doi.org/10.1371/journal.pmed.1004174},
}
