@article{Baillie_J-2023_122459,
title = {The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection},
author = {Baillie, J. and Digard, P. and Goldswain, H. and Dong, X. and Penrice-Randal, R. and Alruwaili, M. and Shawli, G. and Prince, T. and Williamson, M. and Raghwani, J. and Randle, N. and Jones, B. and Donovan-Banfield, I. and Salguero, F. and Tree, J. and Hall, Y. and Hartley, C. and Erdmann, M. and Bazire, J. and Jearanaiwitayakul, T. and Semple, M. and Openshaw, P. and ISARIC4C Investigators and Emmett, S. and Matthews, D. and Turtle, L. and Darby, A. and Davidson, A. and Carroll, M. and Hiscox, J.},
month = {mar},
year = {2023},
abstract = {BACKGROUND: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility. Genomes with D614G are accompanied by a P323L substitution in the viral polymerase (NSP12). However, P323L is not thought to be under strong selective pressure.},
volume = {24},
journal = {Genome Biology},
publisher = {Springer Nature},
url = {https://doi.org/10.1186/s13059-023-02881-5},
}
