@article{Cantoni_D-2023_122662,
title = {Low hanging fruit for combatting SARS‐CoV‐2?},
author = {Cantoni, D. and Grove, J.},
month = {mar},
year = {2023},
abstract = {Entry of SARS-CoV-2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin-converting enzyme-2). This makes ACE2 an attractive target for therapeutic intervention in COVID-19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin-dependent degradation, resulting in the inhibition of SARS-CoV-2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS-2 and related coronaviruses.},
journal = {EMBO Reports},
publisher = {Embopress},
url = {https://doi.org/10.15252/embr.202356979},
}
