@article{Gualano_B-2023_124699,
title = {Physical activity: a strategy to improve antibody response to a SARS-CoV-2 vaccine booster dose in patients with autoimmune rheumatic diseases},
author = {Gualano, B. and Sieczkowska, S. and Pieres da Silva, R. and Pinto, A. and Mazzolani, B. and Smaira, F. and Aikawa, N. and Kupa, L. and Pasoto, S. and Medeiros-Ribeiro, A. and Saad, C. and Yuk, E. and Silva, C. and Swinton, P. and Hallal, P. and Roschel, H. and Lemes, Í. and Bonfa, E.},
month = {mar},
year = {2023},
abstract = {Physical activity associates with improved immunogenicity following a 2-dose schedule of CoronaVac (Sinovac's inactivated SARS-CoV-2 vaccine) in patients with autoimmune rheumatic diseases (ARD). This study evaluates whether physical activity impacts vaccine-induced antibody responses to a booster dose in this population. This was a phase-4 trial conducted in Sao Paulo, Brazil. Patients with ARD underwent a 3-dose schedule of CoronaVac. One month after the booster, we assessed seroconversion rates of anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity. Physical activity was assessed through questionnaire. Physically active (n = 362) and inactive (n = 278) patients were comparable for most characteristics; however, physically active patients were younger (P&lt;.01) and had a lower frequency of chronic inflammatory arthritis (P&lt;.01). Adjusted models showed that physically active patients had -2 times odds of seroconversion rates (OR: 2.09; 95% confidence interval, 1.22 to 3.61), -22% greater geometric mean titers of anti-S1/S2 IgG (22.09%; 95% confidence interval, 3.91 to 65.60), and -7% greater neutralizing activity (6.76%; 95% confidence interval, 2.80 to 10.72) than inactive patients. Patients with ARD who are physically active have greater odds of experiencing better immunogenicity to a booster dose of CoronaVac. These results support the recommendation of physical activity to improve vaccination responses, particularly for immunocompromised individuals.},
pages = {311-316},
volume = {20},
issue = {4},
journal = {Journal of Physical Activity and Health},
publisher = {Human Kinetics},
url = {https://doi.org/10.1123/jpah.2022-0332},
}
