@article{The_COVID-19_Host_Genetics_Initiative-2022_128589,
title = {A first update on mapping the human genetic architecture of COVID-19},
author = {The COVID-19 Host Genetics Initiative},
month = {aug},
year = {2022},
abstract = {The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified. Genes at new loci, includingSFTPD,MUC5BandACE2, reveal compelling insights regarding disease susceptibility and severity.},
pages = {E1-E10},
volume = {608},
journal = {Nature},
publisher = {Springer Nature},
url = {https://doi.org/10.1038/s41586-022-04826-7},
}
