@article{Mangion_K-2020_12860,
title = {The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study},
author = {Mangion, K. and Morrow, A. and Bagot, C. and Bayes, H. and Blyth, K. and Church, C. and Corcoran, D. and Delles, C. and Gillespie, L. and Grieve, D. and Ho, A. and Kean, S. and Lang, N. and Lennie, V. and Lowe, D. and Kellman, P. and Macfarlane, P. and McConnachie, A. and Roditi, G. and Sykes, R. and Touyz, R. and Sattar, N. and Wereski, R. and Wright, S. and Berry, C.},
month = {jul},
year = {2020},
abstract = {Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: &gt;34 ng/L; female: &gt;16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.},
pages = {2185-2196},
volume = {116},
issue = {14},
journal = {Cardiovascular Research},
publisher = {Oxford University Press},
url = {http://dx.doi.org/10.1093/cvr/cvaa209},
}
