@article{Fraser_R-2023_133636,
title = {Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection},
author = {Fraser, R. and Orta-Resendiz, A. and Dockrell, D. and Müller-Trutwin, M. and Mazein, A.},
month = {mar},
year = {2023},
abstract = {Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both.},
volume = {32},
issue = {167},
journal = {European Respiratory Review},
publisher = {European Respiratory Society},
url = {https://doi.org/10.1183/16000617.0197-2022},
}
