@article{George_M-2023_142184,
title = {Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function},
author = {George, M. and Sanchez, J. and Rollings, C. and Fear, D. and Irving, P. and Sinclair, L. and Schurich, A.},
month = {jul},
year = {2023},
abstract = {Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T cell activation is associated with disease severity and may be implicated in producing long-covid symptoms. Here, we assess the role of extracellular vesicles (EV) in regulating T cell function over several weeks post COVID-19 disease. We find that alterations in cellular origin and protein content of EV in COVID-19 convalescence are linked to initial disease severity. We demonstrate that convalescent donor-derived EV can alter the function and metabolic rewiring of CD4 and CD8 T cells. Of note, EV following mild, but not severe disease, show distinctly immune-suppressive properties, reducing T cell effector cytokine production and glucose metabolism. Mechanistically our data indicate the involvement of EV-surface ICAM-1 in facilitating EV—T cell interaction. Our data demonstrate that circulatory EV are phenotypically and functionally altered several weeks following acute infection, suggesting a role for EV as long-term immune modulators.},
volume = {26},
issue = {8},
journal = {iScience},
publisher = {Elsevier},
url = {https://doi.org/10.1016/j.isci.2023.107280},
}
