@article{Baillie_J-2023_145445,
title = {HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation},
author = {Baillie, J. and Yang, H. and Sun, H. and Brackenridge, S. and Zhuang, X. and Wing, P. and Quastel, M. and Walters, L. and Garner, L. and Wang, B. and Yao, X. and Felce, S. and Peng, Y. and Moore, S. and Peeters, B. and Rei, M. and Gomes, J. and Tomas, A. and Davidson, A. and Semple, M. and Turtle, L. and Openshaw, P. and Mentzer, A. and Klenerman, P. and ISARIC4C Investigators and Borrow, P. and Dong, T. and McKeating, J. and Gillespie, G. and McMichael, A.},
month = {jun},
year = {2023},
abstract = {Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E-restricted CD8+ T cell responses in convalescent patients with coronavirus disease 2019. These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia-restricted anti-SARS-CoV-2 CD8+ T cells. HLA-E peptide-specific CD8+ T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. Thus, HLA-E-restricted T cells could contribute to the control of SARS-CoV-2 infection alongside classical T cells.},
volume = {8},
issue = {84},
journal = {Science Immunology},
publisher = {American Association for the Advancement of Science},
url = {https://doi.org/10.1126/sciimmunol.abl8881},
}
