@article{Dee_K-2021_26720,
title = {Human rhinovirus infection blocks SARS-CoV-2 replication within the respiratory epithelium: implications for COVID-19 epidemiology},
author = {Dee, K. and Goldfarb, D. and Haney, J. and Amat, J. and Herder, V. and Stewart, M. and Szemiel, A. and Baguelin, M. and Murcia, P.},
month = {mar},
year = {2021},
abstract = {Virus-virus interactions influence the epidemiology of respiratory infections. However, the impact of viruses causing upper respiratory infections on SARS-CoV-2 replication and transmission is currently unknown. Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans. Interactions between rhinoviruses and co-circulating respiratory viruses have been shown to shape virus epidemiology at the individual host and population level. Here, we examined the replication kinetics of SARS-CoV-2 in the human respiratory epithelium in the presence or absence of rhinovirus. We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. Mathematical simulations show that this virus-virus interaction is likely to have a population-wide effect as an increasing prevalence of rhinovirus will reduce the number of new COVID-19 cases.},
journal = {Journal of Infectious Diseases},
publisher = {Oxford University Press},
url = {https://doi.org/10.1093/infdis/jiab147},
}
