@article{Li_K-2021_26763,
title = {Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface},
author = {Li, K. and Woo, Y. and Stirrup, O. and Hughes, J. and Ho, A. and da Silva Filipe, A. and Johnson, N. and Smollett, K. and Mair, D. and Carmichael, S. and Tong, L. and Nichols, J. and Aranday-Cortes, E. and Brunker, K. and Parr, Y. and Nomikou, K. and McDonald, S. and Niebel, M. and Asamaphan, P. and Sreenu, V. and Robertson, D. and Taggart, A. and Jesudason, N. and Shah, R. and Shepherd, J. and Singer, J. and Taylor, A. and Cousland, Z. and Price, J. and Lees, J. and Jones, T. and Lopez, C. and MacLean, A. and Starinskij, I. and Gunson, R. and Morris, S. and Thomson, P. and Geddes, C. and Traynor, J. and Breuer, J. and Thomson, E. and Mark, P.},
month = {apr},
year = {2021},
abstract = {Objectives: Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium. Methods: We combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations. Results: Of 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated. Conclusions: Near-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.},
pages = {96-103},
volume = {83},
issue = {1},
journal = {Journal of Infection},
publisher = {Elsevier},
url = {http://dx.doi.org/10.1016/j.jinf.2021.04.020},
}
