@article{Aggarwal_K-2020_26764,
title = {Ocular surface manifestations of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis},
author = {Aggarwal, K. and Agarwal, A. and Jaiswal, N. and Dahiya, N. and Ahuja, A. and Mahajan, S. and Tong, L. and Duggal, M. and Singh, M. and Agrawal, R. and Gupta, V.},
month = {nov},
year = {2020},
abstract = {Purpose: This study was performed to determine the occurrence of ocular surface manifestations in patients diagnosed with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: A systematic search of electronic databases i.e. PubMed, Web of Science, CINAHL, OVID and Google scholar was performed using a comprehensive search strategy. The searches were current through 31st May 2020. Pooled data from cross-sectional studies was used for meta-analysis and a narrative synthesis was conducted for studies where a meta-analysis was not feasible. Results: A total of 16 studies reporting 2347 confirmed COVID-19 cases were included. Pooled data showed that 11.64% of COVID-19 patients had ocular surface manifestations. Ocular pain (31.2%), discharge (19.2%), redness (10.8%), and follicular conjunctivitis (7.7%) were the main features. 6.9% patients with ocular manifestations had severe pneumonia. Viral RNA was detected from the ocular specimens in 3.5% patients. Conclusion: The most common reported ocular presentations of COVID-19 included ocular pain, redness, discharge, and follicular conjunctivitis. A small proportion of patients had viral RNA in their conjunctival/tear samples. The available studies show significant publication bias and heterogeneity. Prospective studies with methodical collection and data reporting are needed for evaluation of ocular involvement in COVID-19.},
volume = {15},
issue = {11},
journal = {PLOS ONE},
publisher = {Public Library of Science},
url = {https://doi.org/10.1371/journal.pone.0241661},
}
