@article{Lycett_S-2021_26872,
title = {Epidemic waves of COVID-19 in Scotland: a genomic perspective on the impact of the introduction and relaxation of lockdown on SARS-CoV-2},
author = {Lycett, S. and Hughes, J. and McHugh, M. and da Silva Filipe, A. and Dewar, R. and Lu, L. and Doherty, T. and Shepherd, A. and Inward, R. and Rossi, G. and Balaz, D. and Kao, R. and Rooke, S. and Cotton, S. and Gallagher, M. and Lopez, C. and O'Toole, Á. and Scher, E. and Hill, V. and McCrone, J. and Colquhoun, R. and Jackson, B. and Williams, T. and Williamson, K. and Johnson, N. and Smollett, K. and Mair, D. and Carmichael, S. and Tong, L. and Nichols, J. and Brunker, K. and Shepherd, J. and Li, K. and Aranday-Cortes, E. and Parr, Y. and Broos, A. and Nomikou, K. and McDonald, S. and Niebel, M. and Asamaphan, P. and Starinskij, I. and Jesudason, N. and Shah, R. and Sreenu, V. and Stanton, T. and Shaaban, S. and MacLean, A. and Woolhouse, M. and Gunson, R. and Templeton, K. and Thomson, E. and Rambaut, A. and Holden, M. and Robertson, D.},
month = {jan},
year = {2021},
abstract = {The second SARS virus, SARS-CoV-2, emerged in December 2019, and within a month was globally distributed. It was first introduced into Scotland in February 2020 associated with returning travellers and visitors. By March it was circulating in communities across the UK, and to control COVID-19 cases, and prevent overwhelming of the National Health Service (NHS), a ‘lockdown’ was introduced on 23rd March 2020 with a restriction of people’s movements. To augment the public health efforts a large-scale genome epidemiology effort (as part of the COVID-19 Genomics UK (COG-UK) consortium) resulted in the sequencing of over 5000 SARS-CoV-2 genomes by 18th August 2020 from Scottish cases, about a quarter of the estimated number of cases at that time. Here we quantify the geographical origins of the first wave introductions into Scotland from abroad and other UK regions, the spread of these SARS-CoV-2 lineages to different regions within Scotland (defined at the level of NHS Health Board) and the effect of lockdown on virus ‘success’. We estimate that approximately 300 introductions seeded lineages in Scotland, with around 25% of these lineages composed of more than five viruses, but by June circulating lineages were reduced to low levels, in line with low numbers of recorded positive cases. Lockdown was, thus, associated with a dramatic reduction in infection numbers and the extinguishing of most virus lineages. Unfortunately since the summer cases have been rising in Scotland in a second wave, with &gt;1000 people testing positive on a daily basis, and hospitalisation of COVID-19 cases on the rise again. Examining the available Scottish genome data from the second wave, and comparing it to the first wave, we find that while some UK lineages have persisted through the summer, the majority of lineages responsible for the second wave are new introductions from outside of Scotland and many from outside of the UK. This indicates that, while lockdown in Scotland is directly linked with the first wave case numbers being brought under control, travel-associated imports (mostly from Europe or other parts of the UK) following the easing of lockdown are responsible for seeding the current epidemic population. This demonstrates that the impact of stringent public health measures can be compromised if following this, movements from regions of high to low prevalence are not minimised.},
journal = {MedRxiv},
publisher = {Cold Spring Harbor Laboratory Press},
url = {https://doi.org/10.1101/2021.01.08.20248677},
}
