@article{Faria_N-2021_26896,
title = {Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil},
author = {Faria, N. and Mellan, T. and Whittaker, C. and Claro, I. and Candido, D. and Mishra, S. and Crispim, M. and Sales, F. and Hawryluk, I. and McCrone, J. and Hulswit, R. and Franco, L. and Ramundo, M. and de Jesus, J. and Andrade, P. and Coletti, T. and Ferreira, G. and Silva, C. and Manuli, E. and Pereira, R. and Peixoto, P. and Kraemer, M. and Gaburo, N. and Camilo, C. and Hoeltgebaum, H. and Souza, W. and Rocha, E. and de Souza, L. and de Pinho, M. and Araujo, L. and Malta, F. and de Lima, A. and Silva, J. and Zauli, D. and Ferreira, A. and Schnekenberg, R. and Laydon, D. and Walker, P. and Schlüter, H. and Dos Santos, A. and Vidal, M. and Del Caro, V. and Filho, R. and Dos Santos, H. and Aguiar, R. and Proença-Modena, J. and Nelson, B. and Hay, J. and Monod, M. and Miscouridou, X. and Coupland, H. and Sonabend, R. and Vollmer, M. and Gandy, A. and Prete, C. and Nascimento, V. and Suchard, M. and Bowden, T. and Pond, S. and Wu, C. and Ratmann, O. and Ferguson, N. and Dye, C. and Loman, N. and Lemey, P. and Rambaut, A. and Fraiji, N. and Carvalho, M. and Pybus, O. and Flaxman, S. and Bhatt, S. and Sabino, E.},
month = {apr},
year = {2021},
abstract = {Cases of SARS-CoV-2 infection in Manaus, Brazil, resurged in late 2020, despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1, acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7-2.4-fold more transmissible, and that previous (non-P.1) infection provides 54-79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.},
journal = {Science},
publisher = {American Association for the Advancement of Science},
url = {https://doi.org/10.1126/science.abh2644},
}
